Standard

Brown vs. black hair color

HERC2 · rs3940272

Where this position leads

Condition: Hair Color

rs3940272 Condition: Hair Color Hair Color Condition rs3940272 rs3940272 HERC2

What the study found

Who was studied 10,990 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.638 lower (95% confidence interval 0.5-0.77); p = 4 × 10−20.

Where it sits Chromosome 15, band 15q13.1 — in an intron of HERC2.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Brown vs. black hair color — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Brown vs. black hair color.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Brown vs. black hair color compared to the general population.
Source

Questions about rs3940272

What is rs3940272?

rs3940272 is a single position in the genome, in or near the HERC2 gene. Published research associates it with brown vs. black hair color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3940272 linked to?

On MyGeneLog this position is linked to Hair Color. The research behind each link, and its sources, are set out on that condition page.

Does having rs3940272 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3940272 come from?

GWAS Catalog, Communications biology 2021, PMID:34737440. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Brown vs. black hair color (rs3940272). MyGeneLog™. https://www.mygenelog.com/variants/rs3940272

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