Sensitive

Parkinson's disease

MAPT · rs393152

Where this position leads

Condition: Parkinson's Disease

rs393152 Condition: Parkinson's Disease Parkinson's Disease Condition rs393152 rs393152 MAPT

What the study found

Who was studied 1,713 European ancestry cases, 3,978 European ancestry controls; replicated in 3,361 European ancestry cases, 4,573 European ancestry controls.

The effect Each copy of the A allele carried 1.30 times the odds of Parkinson's disease; p = 2 × 10−16.

How common The A allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — in an intron of LINC02210-CRHR1.

What each result means

A/A Two copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs393152

What is rs393152?

rs393152 is a single position in the genome, in or near the MAPT gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs393152 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs393152?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs393152 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs393152 come from?

GWAS Catalog, Nat Genet 2009, PMID:19915575. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Parkinson's disease (rs393152). MyGeneLog™. https://www.mygenelog.com/variants/rs393152

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