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Clinical endometriosis

GRB14 · rs3920334

Where this position leads

What the study found

Who was studied 36,695 European ancestry cases, 567,775 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0182 higher (95% confidence interval 0.012-0.025); p = 2 × 10⁻⁸.

How common The T allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 2, band 2q24.3 — in an intron of GRB14.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Clinical endometriosis — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Clinical endometriosis.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Clinical endometriosis compared to the general population.

Source

Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations

Koller D, He J, Løkhammer S, Aranda S, Qiu D, Davtian D, Chen Q, Xu Z, Mao Z, Friligkou E, Karaca S, Cormand B

and 5 more — show all

Flores I, Altmäe S, Mitjans M, Cabrera-Mendoza B, Polimanti R

Nature genetics · 2026 · PMID 42056605

Questions about rs3920334

What is rs3920334?

rs3920334 is a single position in the genome, in or near the GRB14 gene. Published research associates it with clinical endometriosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3920334 linked to?

On MyGeneLog this position is linked to Endometriosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs3920334 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3920334 come from?

GWAS Catalog, Nature genetics 2026, PMID:42056605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Clinical endometriosis (rs3920334). MyGeneLog™. https://www.mygenelog.com/variants/rs3920334

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