MYH11 · rs3915499
Where this position leads
Condition: Resting Heart Rate
Strength of the evidence
Its strongest genetic-study result is p = 10−17, with 3 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals; replicated in 130,795 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.303 higher (95% confidence interval 0.23-0.37); p = 1 × 10−17.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 16, band 16p13.11 — in an intron of MYH11.
How common each version is
AG
A 23.6% · G 76.4%
A 22.4% · G 77.6%
A 19.9% · G 80.1%
A 37.1% · G 62.9%
A 37.0% · G 63.0%
A 36.5% · G 63.5%
A 36.9% · G 63.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs3915499 is a single position in the genome, in or near the MYH11 gene. Published research associates it with resting heart rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Resting Heart Rate. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2016, PMID:27798624. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Resting heart rate (rs3915499). MyGeneLog™. https://www.mygenelog.com/variants/rs3915499