Who was studied 5,912 European ancestry cases, 181,740 European ancestry controls.
The effect
Each copy of the T allele carried 1.14 times the odds of Non-melanoma skin cancer (95% confidence interval 1.09-1.18); p = 3 × 10−10.
Where it sits Chromosome 11, band 11q14.3 — in an intron of TYR.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Non-melanoma skin cancer — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Non-melanoma skin cancer.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Non-melanoma skin cancer compared to the general population.
Nature communications · 2018 · PMID 29739929 · open access
Questions about rs3900053
What is rs3900053?
rs3900053 is a single position in the genome, in or near the TYR gene. Published research associates it with non-melanoma skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3900053 linked to?
On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.
Does having rs3900053 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3900053 come from?
GWAS Catalog, Nat Commun 2018, PMID:29739929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.