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Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0187 higher (95% confidence interval 0.013-0.024); p = 2 × 10−10.
Where it sits Chromosome 17, band 17q22 — a missense change in TEX14.
What ClinVar records
ClassificationBenign for TEX14-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-10-30.
ClinVar record 3060802NM_031272.5(TEX14):c.2338A>G (p.Asn780Asp)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Urate levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs389389
What is rs389389?
rs389389 is a single position in the genome, in or near the TEX14 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs389389 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs389389 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs389389 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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