Sensitive

Systemic lupus erythematosus (MTAG)

CLEC16A · rs3893660

Where this position leads

Condition: Systemic Lupus Erythematosus

rs3893660 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs3893660 rs3893660 CLEC16A

What the study found

Who was studied at least 5,877 East Asian ancestry cases, at least 188,588 East Asian ancestry controls, at least 14,355 European ancestry cases, at least 505,956 European ancestry controls, at least 1,393 admixed American ancestry cases, at least 2,327 admixed American ancestry controls (MTAG boosted by autoimmune diseases samples).

The effect Each copy of the A allele shifted the measure 0.09 higher (95% confidence interval 0.075-0.105); p = 3 × 10−31.

Where it sits Chromosome 16, band 16p13.13 — in an intron of CLEC16A.

What each result means

A/A Two copies of the version the research linked to Systemic lupus erythematosus (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Systemic lupus erythematosus (MTAG). That is a smaller link than two copies.
G/G No copy of the version the research linked to Systemic lupus erythematosus (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs3893660

What is rs3893660?

rs3893660 is a single position in the genome, in or near the CLEC16A gene. Published research associates it with systemic lupus erythematosus (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3893660 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs3893660 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3893660 come from?

GWAS Catalog, Nature communications 2023, PMID:36750564. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Systemic lupus erythematosus (MTAG) (rs3893660). MyGeneLog™. https://www.mygenelog.com/variants/rs3893660

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