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Migraine

ASTN2 · rs3891689

Where this position leads

Condition: Migraine

rs3891689 Condition: Migraine Migraine Condition rs3891689 rs3891689 ASTN2

What the study found

Who was studied 102,084 European ancestry cases, 771,257 European ancestry controls.

The effect Each copy of the C allele shifted the measure 1.06 higher (95% confidence interval 1.05-1.07); p = 2 × 10−21.

How common The C allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 9, band 9q33.1 — in an intron of ASTN2.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Migraine compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Migraine.
T/T Published research associates this genotype with typical/baseline likelihood of Migraine — no copies of the reported risk allele.
Source
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K
and 59 more — show all
Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Färkkilä M, Garbrielsen ME, Ghanbari M, Hagen K, Häppölä P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kähönen M, Kristoffersen ES, Kurth T, Lehtimäki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx BWJH, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widén E, van Dijk KW, Aromaa A, Belin AC, Freilinger T, Ikram MA, Järvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefánsson H, Stefansson K, van den Maagdenberg AMJM, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M
International Headache Genetics Consortium · HUNT All-in Headache · Danish Blood Donor Study Genomic Cohort
Nature genetics · 2022 · PMID 35115687 · open access

Questions about rs3891689

What is rs3891689?

rs3891689 is a single position in the genome, in or near the ASTN2 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3891689 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs3891689 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3891689 come from?

GWAS Catalog, Nature genetics 2022, PMID:35115687. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Migraine (rs3891689). MyGeneLog™. https://www.mygenelog.com/variants/rs3891689

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