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White blood cell count (basophil)

IFITM2 · rs3888187

Where this position leads

Condition: Blood Cell Counts

rs3888187 Condition: Blood Cell Counts Blood Cell Counts Condition rs3888187 rs3888187 IFITM2

What the study found

Who was studied 171,846 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0236 higher (95% confidence interval 0.017-0.031); p = 7 × 10−11.

How common The C allele had a frequency of about 51% in the people studied.

Where it sits Chromosome 11, band 11p15.5 — in the 5′ untranslated region of IFITM2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of White blood cell count (basophil) — no copies of the reported risk allele.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White blood cell count (basophil).
C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White blood cell count (basophil) compared to the general population.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs3888187

What is rs3888187?

rs3888187 is a single position in the genome, in or near the IFITM2 gene. Published research associates it with white blood cell count (basophil). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3888187 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs3888187 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3888187 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

White blood cell count (basophil) (rs3888187). MyGeneLog™. https://www.mygenelog.com/variants/rs3888187

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