Sensitive

Coronary artery disease

CUX2 · rs3858704

Where this position leads

Condition: Coronary Artery Disease

rs3858704 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs3858704 rs3858704 CUX2

What the study found

Who was studied 15,302 Japanese ancestry cases, 76,014 European and East Asian ancestry cases, 36,140 Japanese ancestry controls, 264,785 European and East Asian ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Coronary artery disease (95% confidence interval 0.96-1.17); p = 3 × 10−13.

How common The A allele had a frequency of about 66% in the people studied.

Where it sits Chromosome 12, band 12q24.11 — in an intron of CUX2.

What each result means

A/A Two copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
Source

Questions about rs3858704

What is rs3858704?

rs3858704 is a single position in the genome, in or near the CUX2 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3858704 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs3858704 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3858704 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2020, PMID:32469254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary artery disease (rs3858704). MyGeneLog™. https://www.mygenelog.com/variants/rs3858704

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