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COVID-19 (critical illness vs population or mild symptoms)

near TAC4-AS1 · rs3848456

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 5,989 European ancestry cases, 42,891 European ancestry controls.

The effect Each copy of the A allele carried 1.50 times the odds of COVID-19 (critical illness vs population or mild symptoms) (95% confidence interval 1.33-1.7); p = 4 × 10−11.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 17, band 17q21.33 — between genes, 14.4 kb from TAC4-AS1.

What each result means

A/A Two copies of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). That is a smaller link than two copies.
C/C No copy of the version the research linked to COVID-19 (critical illness vs population or mild symptoms). This is the starting point the study compared everyone against.
Source
Whole-genome sequencing reveals host factors underlying critical COVID-19
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS
and 64 more — show all
Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK
GenOMICC investigators · 23andMe investigators · COVID-19 Human Genetics Initiative
Nature · 2022 · PMID 35255492 · open access

Questions about rs3848456

What is rs3848456?

rs3848456 is a single position in the genome, in or near the near TAC4-AS1 gene. Published research associates it with covid-19 (critical illness vs population or mild symptoms). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3848456 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3848456 come from?

GWAS Catalog, Nature 2022, PMID:35255492. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (critical illness vs population or mild symptoms) (rs3848456). MyGeneLog™. https://www.mygenelog.com/variants/rs3848456

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