Standard

Low density lipoprotein cholesterol levels

CERT1 · rs3846663

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 60,405 Hispanic or Latino individuals.

The effect Each copy of the C allele shifted the measure 0.0716 lower (95% confidence interval 0.05-0.093); p = 3 × 10⁻³³.

How common The C allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 5, band 5q13.3 — in an intron of CERT1.

What each result means

C/C Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.

Source

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

Petty LE, Chen HH, Frankel EG, Zhu W, Downie CG, Graff M, Lin P, Sharma P, Zhang X, Scartozzi AC, Roshani R, Landman JM

and 80 more — show all

Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Sim X, Spracklen CN, Zhang W, Preuss M, Bottinger EP, Nadkarni GN, Loos RJF, Chen YI, Tan J, Ipp E, Genter P, Emery LS, Louie T, Sofer T, Stilp AM, Taylor KD, Xiang AH, Buchanan TA, Roll K, Gao C, Palmer ND, Norris JM, Wagenknecht LE, Nousome D, Varma R, McKean-Cowdin R, Guo X, Hai Y, Hsueh W, Sandow K, Parra EJ, Cruz M, Valladares-Salgado A, Wacher-Rodarte N, Rotter JI, Goodarzi MO, Rich SS, Bertoni A, Raffel LJ, Nadler JL, Kandeel FR, Duggirala R, Blangero J, Lehman DM, DeFronzo RA, Thameem F, Wang Y, Gahagan S, Blanco E, Burrows R, Huerta-Chagoya A, Florez JC, Tusie-Luna T, González-Villalpando C, Orozco L, Haiman CA, Hanis CL, Rohde R, Whitsel EA, Reiner AP, Kooperberg C, Li Y, Duan Q, Lee M, Correa-Burrows P, Fried SK, North KE, McCormick JB, Fisher-Hoch SP, Gamazon ER, Morris AP, Mercader JM, Highland HM, Below JE

DIAMANTE Hispanic/Latino Consortium · Global Hispanic Lipids Consortium

Nature communications · 2025 · PMID 40210677 · open access

Questions about rs3846663

What is rs3846663?

rs3846663 is a single position in the genome, in or near the CERT1 gene. Published research associates it with low density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3846663 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3846663 come from?

GWAS Catalog, Nature communications 2025, PMID:40210677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Low density lipoprotein cholesterol levels (rs3846663). MyGeneLog™. https://www.mygenelog.com/variants/rs3846663

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