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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 391,449 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0288 lower (95% confidence interval 0.022-0.035); p = 4 × 10−17.
Where it sits Chromosome 11, band 11p15.5 — in an intron of SIRT3.
What each result means
G/GNo copy of the version the research linked to Platelet distribution width variance. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Platelet distribution width variance. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Platelet distribution width variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40335489 · open access
Questions about rs3843620
What is rs3843620?
rs3843620 is a single position in the genome, in or near the SIRT3 gene. Published research associates it with platelet distribution width variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs3843620 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3843620 come from?
GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Platelet distribution width variance (rs3843620). MyGeneLog™. https://www.mygenelog.com/variants/rs3843620