Type 1 diabetes with ophthalmic manifestations (PheCode 250.13)
INS-IGF2 · rs3842755
2 18123111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 738 African American or Afro-Caribbean cases, 119,755 African American or Afro-Caribbean controls, 2,517 European ancestry cases, 445,450 European ancestry controls, 314 Hispanic or Latin American cases, 59,045 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 0.285 higher (95% confidence interval 0.2-0.37); p = 1 × 10−16.
How common The C allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 11, band 11p15.5 — in an intron of INS-IGF2.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-08-25.
ClinVar record 1275239NC_000011.10:g.2159566C>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Type 1 diabetes with ophthalmic manifestations (PheCode 250.13). This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Type 1 diabetes with ophthalmic manifestations (PheCode 250.13). That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Type 1 diabetes with ophthalmic manifestations (PheCode 250.13). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs3842755
What is rs3842755?
rs3842755 is a single position in the genome, in or near the INS-IGF2 gene. Published research associates it with type 1 diabetes with ophthalmic manifestations (phecode 250.13). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3842755 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs3842755 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3842755 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 18123111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes with ophthalmic manifestations (PheCode 250.13) (rs3842755). MyGeneLog™. https://www.mygenelog.com/variants/rs3842755