Sensitive

Antipsychotic drug-induced weight gain in schizophrenia

PTPRD · rs3824417

Where this position leads

Condition: Schizophrenia

rs3824417 Condition: Schizophrenia Schizophrenia Condition rs3824417 rs3824417 PTPRD

What the study found

Who was studied 1,936 Han Chinese ancestry individuals; replicated in 534 Han Chinese ancestry individuals, 347 European ancestry individuals, 267 African ancestry individuals, 16 individuals.

The effect Each copy of the A allele shifted the measure 5.91 z score higher; p = 3 × 10−9.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 9, band 9p24.1 — a synonymous change in PTPRD.

What each result means

A/A Two copies of the version the research linked to Antipsychotic drug-induced weight gain in schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Antipsychotic drug-induced weight gain in schizophrenia. That is a smaller link than two copies.
G/G No copy of the version the research linked to Antipsychotic drug-induced weight gain in schizophrenia. This is the starting point the study compared everyone against.
Source

Questions about rs3824417

What is rs3824417?

rs3824417 is a single position in the genome, in or near the PTPRD gene. Published research associates it with antipsychotic drug-induced weight gain in schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3824417 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs3824417 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3824417 come from?

GWAS Catalog, Molecular psychiatry 2024, PMID:38336841. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Antipsychotic drug-induced weight gain in schizophrenia (rs3824417). MyGeneLog™. https://www.mygenelog.com/variants/rs3824417

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