Sensitive

Osteoarthritis of the hip or knee

TGFA · rs3821262

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹², with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 39,427 European ancestry cases, 378,169 European ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Osteoarthritis of the hip or knee (95% confidence interval 1.04-1.07); p = 4 × 10⁻¹³.

How common The A allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 2, band 2p13.3 — in an intron of TGFA.

How common each version is

AG

Korean KRGDB

A 40.0% · G 60.0%

Korean Korea4K

A 41.3% · G 58.7%

Korean Korea1K

A 42.4% · G 57.6%

Japanese ToMMo

A 39.3% · G 60.7%

Vietnamese

A 47.2% · G 52.8%

World gnomAD

A 52.2% · G 47.8%

World 1000 Genomes

A 50.9% · G 49.1%

World TOPMed

A 51.8% · G 48.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Osteoarthritis of the hip or knee. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Osteoarthritis of the hip or knee. That is a smaller link than two copies.

G/G No copy of the version the research linked to Osteoarthritis of the hip or knee. This is the starting point the study compared everyone against.

Source

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, Zheng J, Johnson T, Koprulu M, Zengini E, Steinberg J, Wilkinson JM, Bhatnagar S

and 9 more — show all

Hoffman JD, Buchan N, Süveges D, Yerges-Armstrong L, Smith GD, Gaunt TR, Scott RA, McCarthy LC, Zeggini E

arcOGEN Consortium

Nature genetics · 2019 · PMID 30664745 · open access

Questions about rs3821262

What is rs3821262?

rs3821262 is a single position in the genome, in or near the TGFA gene. Published research associates it with osteoarthritis of the hip or knee. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3821262 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs3821262 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3821262 come from?

GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Osteoarthritis of the hip or knee (rs3821262). MyGeneLog™. https://www.mygenelog.com/variants/rs3821262

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