Standard

Diastolic blood pressure

ZNF142 · rs3821033

Where this position leads

What the study found

Who was studied 1,164,961 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.285 mmHg lower (95% confidence interval 0.21-0.36); p = 1 × 10⁻¹³.

How common The T allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 2, band 2q35 — a missense change in ZNF142.

What ClinVar records

Classification Benign for ZNF142-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-05-05. ClinVar record 1279127 NM_001379659.1(ZNF142):c.4537G>A (p.Ala1513Thr)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Diastolic blood pressure. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Diastolic blood pressure. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Diastolic blood pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN

and 269 more — show all

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LifeLines Cohort Study · EPIC-CVD · EPIC-InterAct · Understanding Society Scientific Group · Million Veteran Program

Nature genetics · 2020 · PMID 33230300 · open access

Questions about rs3821033

What is rs3821033?

rs3821033 is a single position in the genome, in or near the ZNF142 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3821033 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs3821033 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3821033 come from?

GWAS Catalog, Nature genetics 2020, PMID:33230300. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diastolic blood pressure (rs3821033). MyGeneLog™. https://www.mygenelog.com/variants/rs3821033

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