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Prostate-specific antigen levels

CLPTM1L · rs381949

Where this position leads

Condition: Prostate-Specific Antigen (PSA) Levels

rs381949 Condition: Prostate-Specific Antigen (PSA) Levels Prostate-Specific Antigen (PSA) Levels Condition rs381949 rs381949 CLPTM1L

What the study found

Who was studied 33,572 Icelandic ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.038 lower (95% confidence interval -); p = 5 × 10−11.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 5, band 5p15.33 — in an intron of CLPTM1L.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate-specific antigen levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate-specific antigen levels.
G/G Published research associates this genotype with typical/baseline likelihood of Prostate-specific antigen levels — no copies of the reported risk allele.
Source
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Gudmundsson J, Sigurdsson JK, Stefansdottir L, Agnarsson BA, Isaksson HJ, Stefansson OA, Gudjonsson SA, Gudbjartsson DF, Masson G, Frigge ML, Stacey SN, Sulem P
and 16 more — show all
Halldorsson GH, Tragante V, Holm H, Eyjolfsson GI, Sigurdardottir O, Olafsson I, Jonsson T, Jonsson E, Barkardottir RB, Hilmarsson R, Asselbergs FW, Geirsson G, Thorsteinsdottir U, Rafnar T, Thorleifsson G, Stefansson K
Nature communications · 2018 · PMID 30410027 · open access

Questions about rs381949

What is rs381949?

rs381949 is a single position in the genome, in or near the CLPTM1L gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs381949 linked to?

On MyGeneLog this position is linked to Prostate-Specific Antigen (PSA) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs381949 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs381949 come from?

GWAS Catalog, Nat Commun 2018, PMID:30410027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Prostate-specific antigen levels (rs381949). MyGeneLog™. https://www.mygenelog.com/variants/rs381949

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