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Who was studied 6,984 European ancestry cases, 708,432 European ancestry controls.
The effect
Each copy of the T allele carried 1.11 times the odds of Bladder cancer (95% confidence interval 1.08-1.15); p = 8 × 10−10.
How common The T allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 18, band 18q12.3 — in an intron of SLC14A1.
What each result means
C/CNo copy of the version the research linked to Bladder cancer. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Bladder cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Bladder cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
JNCI cancer spectrum · 2025 · PMID 39898788 · open access
Questions about rs3819177
What is rs3819177?
rs3819177 is a single position in the genome, in or near the SLC14A1 gene. Published research associates it with bladder cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3819177 linked to?
On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs3819177 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3819177 come from?
GWAS Catalog, JNCI cancer spectrum 2025, PMID:39898788. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bladder cancer (rs3819177). MyGeneLog™. https://www.mygenelog.com/variants/rs3819177