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Who was studied 16,655 Dutch ancestry cases, 48,286 Dutch ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0763 lower (95% confidence interval 0.048-0.104); p = 3 × 10−8.
Where it sits Chromosome 1, band 1p21.2 — in the 3′ untranslated region of PALMD.
What each result means
A/ATwo copies of the version the research linked to Major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Major depressive disorder. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Major depressive disorder. This is the starting point the study compared everyone against.
Molecular psychiatry · 2026 · PMID 42230966 · open access
Questions about rs3818852
What is rs3818852?
rs3818852 is a single position in the genome, in or near the PALMD gene. Published research associates it with major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3818852 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs3818852 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3818852 come from?
GWAS Catalog, Molecular psychiatry 2026, PMID:42230966. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Major depressive disorder (rs3818852). MyGeneLog™. https://www.mygenelog.com/variants/rs3818852