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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the A allele shifted the measure 0.01 mmol/L higher (95% confidence interval 0.01-0.01); p = 6 × 10−12.
Where it sits Chromosome 4, band 4q28.1 — in an intron of SLC25A31.
What each result means
A/ATwo copies of the version the research linked to Cholesterol in Small HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cholesterol in Small HDL. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cholesterol in Small HDL. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs3816588
What is rs3816588?
rs3816588 is a single position in the genome, in or near the SLC25A31 gene. Published research associates it with cholesterol in small hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3816588 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs3816588 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3816588 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 71222Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others2Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cholesterol in Small HDL (rs3816588). MyGeneLog™. https://www.mygenelog.com/variants/rs3816588