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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 29,212 European ancestry cases, 400,539 European ancestry controls, 4,150 East Asian ancestry cases, 155,540 East Asian ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0535 lower (95% confidence interval 0.034-0.073); p = 5 × 10−8.
Where it sits Chromosome 14, band 14q24.2 — between genes, 0.5 kb from DPF3.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation/atrial flutter. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation/atrial flutter. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation/atrial flutter. This is the starting point the study compared everyone against.
rs3814864 is a single position in the genome, in or near the near DPF3 gene. Published research associates it with atrial fibrillation/atrial flutter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3814864 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs3814864 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3814864 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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