Sensitive

Ovarian cancer

BNC2 · rs3814113

Where this position leads

What the study found

Who was studied 1,817 European ancestry cases, 2,353 European ancestry controls; replicated in 6,944 European ancestry cases, 9,477 European ancestry controls.

The effect Each copy of the T allele carried 1.22 times the odds of Ovarian cancer (95% confidence interval 1.16-1.27); p = 5 × 10⁻¹⁹.

How common The T allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 9, band 9p22.2 — between genes, 44.1 kb from BNC2.

What each result means

C/C No copy of the version the research linked to Ovarian cancer. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Ovarian cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Ovarian cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, Wozniak E, Anton-Culver H, Chang-Claude J, Cramer DW, DiCioccio R, Dörk T, Goode EL

and 73 more — show all

Goodman MT, Schildkraut JM, Sellers T, Baglietto L, Beckmann MW, Beesley J, Blaakaer J, Carney ME, Chanock S, Chen Z, Cunningham JM, Dicks E, Doherty JA, Dürst M, Ekici AB, Fenstermacher D, Fridley BL, Giles G, Gore ME, De Vivo I, Hillemanns P, Hogdall C, Hogdall E, Iversen ES, Jacobs IJ, Jakubowska A, Li D, Lissowska J, Lubiński J, Lurie G, McGuire V, McLaughlin J, Medrek K, Moorman PG, Moysich K, Narod S, Phelan C, Pye C, Risch H, Runnebaum IB, Severi G, Southey M, Stram DO, Thiel FC, Terry KL, Tsai YY, Tworoger SS, Van Den Berg DJ, Vierkant RA, Wang-Gohrke S, Webb PM, Wilkens LR, Wu AH, Yang H, Brewster W, Ziogas A, Houlston R, Tomlinson I, Whittemore AS, Rossing MA, Ponder BA, Pearce CL, Ness RB, Menon U, Kjaer SK, Gronwald J, Garcia-Closas M, Fasching PA, Easton DF, Chenevix-Trench G, Berchuck A, Pharoah PD, Gayther SA

Australian Cancer (Ovarian) Study · Australian Ovarian Cancer Study Group · Ovarian Cancer Association Consortium

Nature genetics · 2009 · PMID 19648919

Questions about rs3814113

What is rs3814113?

rs3814113 is a single position in the genome, in or near the BNC2 gene. Published research associates it with ovarian cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3814113 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs3814113 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3814113 come from?

GWAS Catalog, Nat Genet 2009, PMID:19648919. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ovarian cancer (rs3814113). MyGeneLog™. https://www.mygenelog.com/variants/rs3814113

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