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Sphingomyeline C18:0 levels

ITGB3 · rs3809863

What the study found

Who was studied 31,120 Caucasian ancestry individuals.

The effect Each copy of the T allele shifted the measure 6.37 (zscore) higher; p = 2 × 10−10.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 17, band 17q21.32 — a synonymous change in ITGB3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Sphingomyeline C18:0 levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sphingomyeline C18:0 levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sphingomyeline C18:0 levels compared to the general population.
Source

Questions about rs3809863

What is rs3809863?

rs3809863 is a single position in the genome, in or near the ITGB3 gene. Published research associates it with sphingomyeline c18:0 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3809863 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3809863 come from?

GWAS Catalog, Nature genetics 2021, PMID:33414548. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sphingomyeline C18:0 levels (rs3809863). MyGeneLog™. https://www.mygenelog.com/variants/rs3809863

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