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Gastric cancer

TTC33 · rs3805495

Where this position leads

Condition: Non-Cardia Gastric Cancer

rs3805495 Condition: Non-Cardia Gastric Cancer Non-Cardia Gastric Cancer Condition rs3805495 rs3805495 TTC33

What the study found

Who was studied 6,563 Japanese ancestry cases, 195,745 Japanese ancestry controls.

The effect Each copy of the T allele carried 0.85 times the odds of Gastric cancer (95% confidence interval 0.817886381-0.878279842); p = 9 × 10−20.

How common The T allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 5, band 5p13.1 — in an intron of TTC33.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs3805495

What is rs3805495?

rs3805495 is a single position in the genome, in or near the TTC33 gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3805495 linked to?

On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs3805495 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3805495 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gastric cancer (rs3805495). MyGeneLog™. https://www.mygenelog.com/variants/rs3805495

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