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Body shape phenotype PC3

NPR3 · rs3792752

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−300, with 6 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 460,198 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0225 lower (95% confidence interval 0.018-0.026); p = 5 × 10−28.

How common The A allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 5, band 5p13.3 — in an intron of NPR3.

What each result means

A/A Two copies of the version the research linked to Body shape phenotype PC3. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Body shape phenotype PC3. That is a smaller link than two copies.
G/G No copy of the version the research linked to Body shape phenotype PC3. This is the starting point the study compared everyone against.
Source

Questions about rs3792752

What is rs3792752?

rs3792752 is a single position in the genome, in or near the NPR3 gene. Published research associates it with body shape phenotype pc3. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3792752 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3792752 come from?

GWAS Catalog, Science advances 2024, PMID:38640244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body shape phenotype PC3 (rs3792752). MyGeneLog™. https://www.mygenelog.com/variants/rs3792752

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