ERGIC3 · rs3790136
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 4 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.039 higher; p = 4 × 10−10.
How common The A allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 20, band 20q11.22 — in an intron of ERGIC3.
How common each version is
AT
A 85.9% · T 14.1%
A 86.9% · T 13.1%
A 89.0% · T 11.0%
A 85.2% · T 14.8%
A 79.5% · T 20.5%
A 77.5% · T 22.5%
A 78.9% · T 21.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs3790136 is a single position in the genome, in or near the ERGIC3 gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2018, PMID:29507422. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Total cholesterol levels (rs3790136). MyGeneLog™. https://www.mygenelog.com/variants/rs3790136