Gene Knowledge Graph
UTC
Standard

Alopecia areata

ACOXL · rs3789129

Where this position leads

Condition: Alopecia Areata

rs3789129 Condition: Alopecia Areata Alopecia Areata Condition rs3789129 rs3789129 ACOXL

What the study found

Who was studied 2,332 European ancestry cases and 5,233 European ancestry controls; replicated in 764 European ancestry cases and 2,256 European ancestry controls.

The effect Each copy of the A allele carried 1.31 times the odds of Alopecia areata (95% confidence interval -); p = 2 × 10−8.

Where it sits Chromosome 2, band 2q13 — in an intron of ACOXL.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alopecia areata compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alopecia areata.
C/C Published research associates this genotype with typical/baseline likelihood of Alopecia areata — no copies of the reported risk allele.
Source
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci
Betz RC, Petukhova L, Ripke S, Huang H, Menelaou A, Redler S, Becker T, Heilmann S, Yamany T, Duvic M, Hordinsky M, Norris D
and 21 more — show all
Price VH, Mackay-Wiggan J, de Jong A, DeStefano GM, Moebus S, Böhm M, Blume-Peytavi U, Wolff H, Lutz G, Kruse R, Bian L, Amos CI, Lee A, Gregersen PK, Blaumeiser B, Altshuler D, Clynes R, de Bakker PIW, Nöthen MM, Daly MJ, Christiano AM
Nature communications · 2015 · PMID 25608926 · open access

Questions about rs3789129

What is rs3789129?

rs3789129 is a single position in the genome, in or near the ACOXL gene. Published research associates it with alopecia areata. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3789129 linked to?

On MyGeneLog this position is linked to Alopecia Areata. The research behind each link, and its sources, are set out on that condition page.

Does having rs3789129 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3789129 come from?

GWAS Catalog, Nat Commun 2015, PMID:25608926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alopecia areata (rs3789129). MyGeneLog™. https://www.mygenelog.com/variants/rs3789129

← See all variants