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Who was studied 13,746 East Asian ancestry cases, 241,425 East Asian ancestry controls, 17,969 European ancestry cases, 702,230 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Kidney stone disease (95% confidence interval 1.08-1.14); p = 2 × 10−17.
How common The A allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 22, band 22q11.22 — in an intron of RSPH14.
What each result means
A/ATwo copies of the version the research linked to Kidney stone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Kidney stone disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Kidney stone disease. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40216741 · open access
Questions about rs3788338
What is rs3788338?
rs3788338 is a single position in the genome, in or near the RSPH14 gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3788338 linked to?
On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs3788338 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3788338 come from?
GWAS Catalog, Nature communications 2025, PMID:40216741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 72122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others2Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney stone disease (rs3788338). MyGeneLog™. https://www.mygenelog.com/variants/rs3788338