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HDL cholesterol levels

LIPG · rs3786247

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs3786247 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs3786247 rs3786247 LIPG

What the study found

Who was studied 34,930 East Asian ancestry individuals, 187,167 European ancestry individuals; replicated in 8,741 Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.094 lower (95% confidence interval 0.074-0.114); p = 7 × 10−19.

How common The T allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 18, band 18q21.1 — in the 3′ untranslated region of LIPG.

What each result means

G/G No copy of the version the research linked to HDL cholesterol levels. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to HDL cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3786247

What is rs3786247?

rs3786247 is a single position in the genome, in or near the LIPG gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3786247 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs3786247 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3786247 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28334899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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HDL cholesterol levels (rs3786247). MyGeneLog™. https://www.mygenelog.com/variants/rs3786247

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