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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−16, with 9 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 116,707 African American or Afro-Caribbean individuals, 57,141 Hispanic or Latin American individuals, 6,285 East Asian ancestry individuals, 421,411 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0258 higher (95% confidence interval 0.02-0.032); p = 1 × 10−16.
How common The G allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 16, band 16q22.1 — in an intron of PRMT7.
How common each version is
GT
By ancestry gnomAD
East Asian
G 14.5% · T 85.5%
European (non-Finnish)
G 28.9% · T 71.1%
African / African American
G 5.8% · T 94.2%
South Asian
G 30.5% · T 69.5%
Admixed American (Latino)
G 22.5% · T 77.5%
Middle Eastern
G 33.9% · T 66.1%
Finnish
G 28.1% · T 71.9%
Ashkenazi Jewish
G 35.4% · T 64.6%
The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.
What each result means
G/GTwo copies of the version the research linked to creatinine (mean, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to creatinine (mean, inv-norm transformed). That is a smaller link than two copies.
T/TNo copy of the version the research linked to creatinine (mean, inv-norm transformed). This is the starting point the study compared everyone against.
DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
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