PSMC3 · rs3781627
Where this position leads
Condition: Medication Use as a Genetic Trait
What the study found
Who was studied 24,832 European ancestry cases, 280,750 European ancestry controls.
The effect Each copy of the T allele shifted the measure 0.0565 higher (95% confidence interval 0.037-0.076); p = 3 × 10−8.
How common The T allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 11, band 11p11.2 — in an intron of PSMC3.
rs3781627 is a single position in the genome, in or near the PSMC3 gene. Published research associates it with medication use (thyroid preparations). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Medication use (thyroid preparations) (rs3781627). MyGeneLog™. https://www.mygenelog.com/variants/rs3781627