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Alanine aminotransferase levels

ZNF76 · rs3777742

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 344,136 European ancestry individuals, 150,545 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0169 lower (95% confidence interval 0.013-0.021); p = 5 × 10−14.

Where it sits Chromosome 6, band 6p21.31 — in an intron of ZNF76.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Alanine aminotransferase levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alanine aminotransferase levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alanine aminotransferase levels compared to the general population.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs3777742

What is rs3777742?

rs3777742 is a single position in the genome, in or near the ZNF76 gene. Published research associates it with alanine aminotransferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3777742 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3777742 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Alanine aminotransferase levels (rs3777742). MyGeneLog™. https://www.mygenelog.com/variants/rs3777742

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