near H2BC21 · rs377742228
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect Each copy of the G allele shifted the measure 0.02 mmol/L higher (95% confidence interval 0.02-0.02); p = 1 × 10−10.
Where it sits Chromosome 1, band 1q21.2 — between genes, 11.2 kb from H2BC21.
rs377742228 is a single position in the genome, in or near the near H2BC21 gene. Published research associates it with phospholipid levels in chylomicrons and extremely large vldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Phospholipid levels in chylomicrons and extremely large VLDL (rs377742228). MyGeneLog™. https://www.mygenelog.com/variants/rs377742228