DNMT3A · rs377577594
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What ClinVar records
Classification
Pathogenic/Likely pathogenic for Acute myeloid leukemia, Tatton-Brown-Rahman overgrowth syndrome, Inborn genetic diseases, Neurodevelopmental disorder, EBV-positive nodal T- and NK-cell lymphoma and 3 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 20 submitters), last evaluated 2026-02-01.
ClinVar record 375882 NM_022552.5(DNMT3A):c.2644C>T (p.Arg882Cys)
Classification
Conflicting classifications of pathogenicity for Tatton-Brown-Rahman overgrowth syndrome; criteria provided, conflicting classifications (1 of 4 stars, 3 submitters), last evaluated 2026-01-01.
ClinVar record 375884 NM_022552.5(DNMT3A):c.2644C>A (p.Arg882Ser)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
Source: ClinVar VCV000375882, criteria provided, multiple submitters, no conflicts
rs377577594 is a single position in the genome, in or near the DNMT3A gene. Published research associates it with acute myeloid leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
ClinVar VCV000375882, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Acute myeloid leukemia (rs377577594). MyGeneLog™. https://www.mygenelog.com/variants/rs377577594