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Body size at age 10

CACNA1D · rs3774604

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 453,169 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.00794 higher (95% confidence interval 0.0051-0.0108); p = 5 × 10⁻⁸.

How common The C allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 3, band 3p21.1 — in an intron of CACNA1D.

What each result means

C/C Two copies of the version the research linked to Body size at age 10. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Body size at age 10. That is a smaller link than two copies.

T/T No copy of the version the research linked to Body size at age 10. This is the starting point the study compared everyone against.

Source

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G

BMJ (Clinical research ed.) · 2020 · PMID 32376654 · open access

Questions about rs3774604

What is rs3774604?

rs3774604 is a single position in the genome, in or near the CACNA1D gene. Published research associates it with body size at age 10. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3774604 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3774604 come from?

GWAS Catalog, BMJ (Clinical research ed.) 2020, PMID:32376654. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body size at age 10 (rs3774604). MyGeneLog™. https://www.mygenelog.com/variants/rs3774604

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