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Standard

HDL cholesterol

MBNL1 · rs3773910

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 215,551 European ancestry individuals, 57,332 African American individuals, 24,743 Hispanic individuals; replicated in Up to 319,677 individuals.

The effect Each copy of the C allele shifted the measure 0.0161 mg dl-1 lower (95% confidence interval 0.011-0.021); p = 1 × 10−10.

How common The C allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 3, band 3q25.2 — in an intron of MBNL1.

How common each version is

CG
Korean KRGDB
C 73.7% · G 26.4%
Korean Korea4K
C 74.7% · G 25.3%
Korean Korea1K
C 74.0% · G 26.0%
Japanese ToMMo
C 77.2% · G 22.8%
Vietnamese
C 82.5% · G 17.4%
World gnomAD
C 78.1% · G 21.9%
World 1000 Genomes
C 78.0% · G 22.0%
World TOPMed
C 77.5% · G 22.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
G/G No copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
Source
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li J, Peloso GM, Chaffin M, Small AM
and 33 more — show all
Huang J, Tang H, Lynch JA, Ho YL, Liu DJ, Emdin CA, Li AH, Huffman JE, Lee JS, Natarajan P, Chowdhury R, Saleheen D, Vujkovic M, Baras A, Pyarajan S, Di Angelantonio E, Neale BM, Naheed A, Khera AV, Danesh J, Chang KM, Abecasis G, Willer C, Dewey FE, Carey DJ, Concato J, Gaziano JM, O'Donnell CJ, Tsao PS, Kathiresan S, Rader DJ, Wilson PWF, Assimes TL
Global Lipids Genetics Consortium · Myocardial Infarction Genetics (MIGen) Consortium · Geisinger-Regeneron DiscovEHR Collaboration · VA Million Veteran Program
Nature genetics · 2018 · PMID 30275531 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

HDL cholesterol (rs3773910). MyGeneLog™. https://www.mygenelog.com/variants/rs3773910

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