Sensitive

Osteoarthritis

TGFA · rs3771501

Where this position leads

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Osteoarthritis — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis compared to the general population.

Source

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, Zheng J, Johnson T, Koprulu M, Zengini E, Steinberg J, Wilkinson JM, Bhatnagar S

and 9 more — show all

Hoffman JD, Buchan N, Süveges D, Yerges-Armstrong L, Smith GD, Gaunt TR, Scott RA, McCarthy LC, Zeggini E

arcOGEN Consortium

Nature genetics · 2019 · PMID 30664745 · open access

Questions about rs3771501

What is rs3771501?

rs3771501 is a single position in the genome, in or near the TGFA gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3771501 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs3771501 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3771501 come from?

GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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