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Estimated glomerular filtration rate

LRP2 · rs3770636

What the study found

Who was studied 206,856 European ancestry individuals, 143,658 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 9.72 z score higher; p = 3 × 10−22.

How common The G allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 2, band 2q31.1 — in an intron of LRP2.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Estimated glomerular filtration rate compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Estimated glomerular filtration rate.
T/T Published research associates this genotype with typical/baseline likelihood of Estimated glomerular filtration rate — no copies of the reported risk allele.
Source

Questions about rs3770636

What is rs3770636?

rs3770636 is a single position in the genome, in or near the LRP2 gene. Published research associates it with estimated glomerular filtration rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3770636 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3770636 come from?

GWAS Catalog, Nature communications 2019, PMID:31015462. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Estimated glomerular filtration rate (rs3770636). MyGeneLog™. https://www.mygenelog.com/variants/rs3770636

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