Gene Knowledge Graph
UTC
Sensitive

Type 2 diabetes

MACF1 · rs3768321

Where this position leads

Condition: Type 2 Diabetes

rs3768321 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs3768321 rs3768321 MACF1

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Type 2 diabetes — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 diabetes.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 diabetes compared to the general population.
Source
Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility
Cook JP, Morris AP
European journal of human genetics : EJHG · 2016 · PMID 27189021 · open access

Questions about rs3768321

What is rs3768321?

rs3768321 is a single position in the genome, in or near the MACF1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3768321 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs3768321 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3768321 come from?

GWAS Catalog, Eur J Hum Genet 2016, PMID:27189021. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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