Standard

Waist-hip ratio

PROX1 · rs3767848

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

rs3767848 Condition: Waist-to-Hip Ratio (Body Fat Distribution) Waist-to-Hip Ratio (Body Fat Distri… Condition rs3767848 rs3767848 PROX1

What the study found

Who was studied 697,734 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0124 lower (95% confidence interval 0.0083-0.0165); p = 2 × 10−9.

How common The A allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 1, band 1q32.3 — in an intron of PROX1.

What each result means

A/A Two copies of the version the research linked to Waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Waist-hip ratio. That is a smaller link than two copies.
G/G No copy of the version the research linked to Waist-hip ratio. This is the starting point the study compared everyone against.
Source

Questions about rs3767848

What is rs3767848?

rs3767848 is a single position in the genome, in or near the PROX1 gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3767848 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs3767848 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3767848 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Waist-hip ratio (rs3767848). MyGeneLog™. https://www.mygenelog.com/variants/rs3767848

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