SPINK5 · rs3764930
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,255 European, Hispanic or African ancestry individuals; replicated in 325 Arab, Indian or Filipino ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.257 lower (95% confidence interval 0.19-0.32); p = 5 × 10−14.
How common The G allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 5, band 5q32 — in an intron of SPINK5.
What ClinVar records
Classification
Benign/Likely benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-01-08.
ClinVar record 403487 NM_006846.4(SPINK5):c.2740-170G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs3764930 is a single position in the genome, in or near the SPINK5 gene. Published research associates it with q9nq38-3 protein level (protein group normalized intensity). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:41310232. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Q9NQ38-3 protein level (protein group normalized intensity) (rs3764930). MyGeneLog™. https://www.mygenelog.com/variants/rs3764930