Alzheimer's disease, proxy Alzheimer's disease or related dementias
near RNU6-1325P · rs376291994
0 172114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 128,681 European ancestry cases, 849,833 European ancestry controls.
The effect
Each copy of the G allele carried 1.52 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias (95% confidence interval 1.32-1.76); p = 6 × 10−9.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 4, band 4q13.1 — between genes, 150 kb from RNU6-1325P.
What each result means
A/ANo copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs376291994
What is rs376291994?
rs376291994 is a single position in the genome, in or near the near RNU6-1325P gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs376291994 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs376291994 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs376291994 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 172114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease, proxy Alzheimer's disease or related dementias (rs376291994). MyGeneLog™. https://www.mygenelog.com/variants/rs376291994