0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,020 African American or Afro-Caribbean cases, 120,535 African American or Afro-Caribbean controls, 1,672 European ancestry cases, 448,997 European ancestry controls, 279 Hispanic or Latin American cases, 59,541 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 4.08 lower (95% confidence interval 4.07-4.09); p = 2 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 7, band 7q21.11 — in an intron of PCLO.
What each result means
A/ANo copy of the version the research linked to Graves' disease (PheCode 242.1). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Graves' disease (PheCode 242.1). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Graves' disease (PheCode 242.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs376091074
What is rs376091074?
rs376091074 is a single position in the genome, in or near the PCLO gene. Published research associates it with graves' disease (phecode 242.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs376091074 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs376091074 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs376091074 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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