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Photoreceptor cell layer thickness phenotypes (MTAG)

near AURKBP1 · rs376067714

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 31,135 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.77 higher (95% confidence interval 0.61-0.93); p = 3 × 10⁻²⁴.

How common The G allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 8, band 8q23.1 — between genes, 1.5 kb from AURKBP1.

What each result means

A/A No copy of the version the research linked to Photoreceptor cell layer thickness phenotypes (MTAG). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Photoreceptor cell layer thickness phenotypes (MTAG). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Photoreceptor cell layer thickness phenotypes (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation

Currant H, Fitzgerald TW, Patel PJ, Khawaja AP, Webster AR, Mahroo OA, Birney E

UK Biobank Eye and Vision Consortium

PLoS genetics · 2023 · PMID 36848389 · open access

Questions about rs376067714

What is rs376067714?

rs376067714 is a single position in the genome, in or near the near AURKBP1 gene. Published research associates it with photoreceptor cell layer thickness phenotypes (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs376067714 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs376067714 come from?

GWAS Catalog, PLoS genetics 2023, PMID:36848389. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Photoreceptor cell layer thickness phenotypes (MTAG) (rs376067714). MyGeneLog™. https://www.mygenelog.com/variants/rs376067714

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