Standard

Creatinine levels

ARHGAP26 · rs3756374

Where this position leads

Condition: Kidney Function

rs3756374 Condition: Kidney Function Kidney Function Condition rs3756374 rs3756374 ARHGAP26

What the study found

Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0078 higher (95% confidence interval 0.0051-0.0105); p = 3 × 10−8.

Where it sits Chromosome 5, band 5q31.3 — in an intron of ARHGAP26.

What each result means

G/G No copy of the version the research linked to Creatinine levels. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Creatinine levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Creatinine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3756374

What is rs3756374?

rs3756374 is a single position in the genome, in or near the ARHGAP26 gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3756374 linked to?

On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.

Does having rs3756374 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3756374 come from?

GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Creatinine levels (rs3756374). MyGeneLog™. https://www.mygenelog.com/variants/rs3756374

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