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Major depressive disorder (broad)

PCDHA4 · rs3756335

Where this position leads

Condition: Major Depressive Disorder

rs3756335 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs3756335 rs3756335 PCDHA4

What the study found

Who was studied 258,364 European ancestry cases, 571,252 European ancestry controls, 36,818 African ancestry cases, 161,679 African ancestry controls, 21,980 East Asian ancestry cases, 360,956 East Asian ancestry controls, 4,505 South Asian ancestry cases, 27,176 South Asian ancestry controls, 25,013 Hispanic or Latin American cases, 352,946 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.018 lower (95% confidence interval 0.012-0.024); p = 3 × 10−9.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 5, band 5q31.3 — in an intron of PCDHA4.

What each result means

A/A Two copies of the version the research linked to Major depressive disorder (broad). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Major depressive disorder (broad). That is a smaller link than two copies.
T/T No copy of the version the research linked to Major depressive disorder (broad). This is the starting point the study compared everyone against.
Source
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM
and 66 more — show all
Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S, Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K
PGC-MDD Working Group · China Kadoorie Biobank Collaborative Group · 23andMe Research Team · Genes and Health Research Team · BioBank Japan Project
Nature genetics · 2024 · PMID 38177345 · open access

Questions about rs3756335

What is rs3756335?

rs3756335 is a single position in the genome, in or near the PCDHA4 gene. Published research associates it with major depressive disorder (broad). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3756335 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs3756335 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3756335 come from?

GWAS Catalog, Nature genetics 2024, PMID:38177345. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Major depressive disorder (broad) (rs3756335). MyGeneLog™. https://www.mygenelog.com/variants/rs3756335

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