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REM sleep behavior disorder (probable or isolated)

SNCA · rs3756059

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,843 European ancestry cases, 139,636 European ancestry controls.

The effect Each copy of the A allele carried 1.26 times the odds of REM sleep behavior disorder (probable or isolated) (95% confidence interval 1.19-1.33); p = 3 × 10−16.

How common The A allele had a frequency of about 50% in the people studied.

Where it sits Chromosome 4, band 4q22.1 — in an intron of SNCA.

What each result means

A/A Two copies of the version the research linked to REM sleep behavior disorder (probable or isolated). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to REM sleep behavior disorder (probable or isolated). That is a smaller link than two copies.
G/G No copy of the version the research linked to REM sleep behavior disorder (probable or isolated). This is the starting point the study compared everyone against.
Source
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Krohn L, Heilbron K, Blauwendraat C, Reynolds RH, Yu E, Senkevich K, Rudakou U, Estiar MA, Gustavsson EK, Brolin K, Ruskey JA, Freeman K
and 46 more — show all
Asayesh F, Chia R, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Högl B, Stefani A, Ibrahim A, Šonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Biscarini F, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Scholz SW, Ryten M, Bandres-Ciga S, Noyce A, Cannon P, Pihlstrøm L, Nalls MA, Singleton AB, Rouleau GA, Postuma RB, Gan-Or Z
23andMe Research Team
Nature communications · 2022 · PMID 36470867 · open access

Questions about rs3756059

What is rs3756059?

rs3756059 is a single position in the genome, in or near the SNCA gene. Published research associates it with rem sleep behavior disorder (probable or isolated). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs3756059 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3756059 come from?

GWAS Catalog, Nature communications 2022, PMID:36470867. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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REM sleep behavior disorder (probable or isolated) (rs3756059). MyGeneLog™. https://www.mygenelog.com/variants/rs3756059

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