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Mean arterial pressure

NEK10 · rs3755652

Where this position leads

What the study found

Who was studied 120,473 European ancestry individuals, 21,503 African American individuals, 4,586 Hispanic individuals.

The effect Each copy of the T allele shifted the measure 0.307 higher (95% confidence interval 0.2-0.42); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 3, band 3p24.1 — a missense change in SLC4A7.

What each result means

C/C No copy of the version the research linked to Mean arterial pressure. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Mean arterial pressure. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Mean arterial pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, Guo X, Palmas W

and 83 more — show all

Martin LW, Chen YD, Surendran P, Drenos F, Cook JP, Auer PL, Chu AY, Giri A, Zhao W, Jakobsdottir J, Lin LA, Stafford JM, Amin N, Mei H, Yao J, Voorman A, Larson MG, Grove ML, Smith AV, Hwang SJ, Chen H, Huan T, Kosova G, Stitziel NO, Kathiresan S, Samani N, Schunkert H, Deloukas P, Li M, Fuchsberger C, Pattaro C, Gorski M, Kooperberg C, Papanicolaou GJ, Rossouw JE, Faul JD, Kardia SL, Bouchard C, Raffel LJ, Uitterlinden AG, Franco OH, Vasan RS, O'Donnell CJ, Taylor KD, Liu K, Bottinger EP, Gottesman O, Daw EW, Giulianini F, Ganesh S, Salfati E, Harris TB, Launer LJ, Dörr M, Felix SB, Rettig R, Völzke H, Kim E, Lee WJ, Lee IT, Sheu WH, Tsosie KS, Edwards DR, Liu Y, Correa A, Weir DR, Völker U, Ridker PM, Boerwinkle E, Gudnason V, Reiner AP, van Duijn CM, Borecki IB, Edwards TL, Chakravarti A, Rotter JI, Psaty BM, Loos RJ, Fornage M, Ehret GB, Newton-Cheh C, Levy D, Chasman DI

CHD Exome+ Consortium · ExomeBP Consortium · GoT2DGenes Consortium · T2D-GENES Consortium · Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia · CKDGen Consortium

Nature genetics · 2016 · PMID 27618448

Questions about rs3755652

What is rs3755652?

rs3755652 is a single position in the genome, in or near the NEK10 gene. Published research associates it with mean arterial pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3755652 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs3755652 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3755652 come from?

GWAS Catalog, Nat Genet 2016, PMID:27618448. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Mean arterial pressure (rs3755652). MyGeneLog™. https://www.mygenelog.com/variants/rs3755652

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