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Vitamin D levels

UGT1A10 · rs3755322

Where this position leads

Condition: Gout

What the study found

Who was studied 327,435 European ancestry individuals, 5,845 African ancestry individuals, 6,425 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0508 lower (95% confidence interval 0.042-0.059); p = 7 × 10⁻³².

Where it sits Chromosome 2, band 2q37.1 — a missense change in UGT1A5.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Vitamin D levels — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitamin D levels.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitamin D levels compared to the general population.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs3755322

What is rs3755322?

rs3755322 is a single position in the genome, in or near the UGT1A10 gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3755322 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs3755322 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3755322 come from?

GWAS Catalog, Nat Genet 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vitamin D levels (rs3755322). MyGeneLog™. https://www.mygenelog.com/variants/rs3755322

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